AustralieFrV1, Main, Exploration, bibRecord, 004266

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Identifieur interne : 004266 ( Main/Exploration ); précédent : 004265; suivant : 004267

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Auteurs : YUTING MA [France] ; Stephen R. Mattarollo [Australie] ; Sandy Adjemian [France] ; HENG YANG [France] ; Laetitia Aymeric [France] ; Dalil Hannani [France] ; João Paulo Portela Catani [France, Brésil] ; Helene Duret [Australie] ; Michele W. L. Teng [Australie] ; Oliver Kepp [France] ; YIDAN WANG [France] ; Antonella Sistigu [France] ; Joachim L. Schultze [Allemagne] ; Gautier Stoll [France] ; Lorenzo Galluzzi [France] ; Laurence Zitvogel [France] ; Mark J. Smyth [Australie] ; Guido Kroemer [France]

Source :

Cancer research : (Chicago, Ill.) [ 0008-5472 ] ; 2014.

RBID : Pascal:14-0102965

Descripteurs français

Pascal (Inist)
- Protéine MCP1, Chimiokine CC, Récepteur chimiokine, Récepteur chimiokine CCR2, Recrutement, Cellule accessoire, Cellule APC, Tumeur maligne, Chimiothérapie, Chimiokine CCL2.
Wicri :
- topic : Recrutement.

English descriptors

KwdEn :
- Accessory cell, Antigen presenting cell, CC chemokine, CC-chemokine ligand 2, CCR2 chemokine receptor, Chemokine receptor, Chemotherapy, Malignant tumor, Monocyte chemoattractant protein 1, Recruitment.

Abstract

The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell- and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b⁺CD11c⁺Ly6C^highLy6G^-MHCII⁺ dendritic cell-like antigen-presenting cells (APC) into the tumor bed, but not into lymphoid organs. Accordingly, draining lymph nodes turned out to be dispensable for the proliferation of tumor antigen-specific T cells within neoplastic lesions as induced by anthracyclines. In addition, we found that tumors treated with anthracyclines manifest increased expression levels of the chemokine Ccl2. Such a response is important as neoplasms growing in Ccl2^-/- mice failed to accumulate dendritic cell-like APCs in response to chemotherapy. Moreover, cancers developing in mice lacking Ccl2 or its receptor (Ccr2) exhibited suboptimal therapeutic responses to anthracycline-based chemotherapy. Altogether, our results underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U1015, CBT1017</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CBT1017</wicri:noRegion>
<wicri:noRegion>INSERM, U1015, CBT1017</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L." last="Schultze">Joachim L. Schultze</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Genomics & Immunoregulation, LIMES-Institute, University of Bonn</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stoll, Gautier" sort="Stoll, Gautier" uniqKey="Stoll G" first="Gautier" last="Stoll">Gautier Stoll</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U1015, CBT1017</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CBT1017</wicri:noRegion>
<wicri:noRegion>INSERM, U1015, CBT1017</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre</s1>
<s2>East Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>East Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>School of Medicine, University of Queensland</s1>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>School of Medicine, University of Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s2>Herston, Queensland</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Herston, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Metabolomics and Cell Biology Platforms, Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Pole de Biologie, Hôpital Européen Georges Pompidou, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
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<idno type="inist">14-0102965</idno>
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<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000414</idno>
<idno type="wicri:doubleKey">0008-5472:2014:Yuting Ma:ccl:ccr:dependent</idno>
<idno type="wicri:Area/Main/Merge">004338</idno>
<idno type="wicri:Area/Main/Curation">004266</idno>
<idno type="wicri:Area/Main/Exploration">004266</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy</title>
<author><name sortKey="Yuting Ma" sort="Yuting Ma" uniqKey="Yuting Ma" last="Yuting Ma">YUTING MA</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mattarollo, Stephen R" sort="Mattarollo, Stephen R" uniqKey="Mattarollo S" first="Stephen R." last="Mattarollo">Stephen R. Mattarollo</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre</s1>
<s2>East Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>East Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Diamantina Institute</s1>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Diamantina Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heng Yang" sort="Heng Yang" uniqKey="Heng Yang" last="Heng Yang">HENG YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>INSERM, UMR996, LabEx LERMIT</s1>
<s2>Clamart</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Clamart</wicri:noRegion>
<wicri:noRegion>LabEx LERMIT</wicri:noRegion>
<wicri:noRegion>Clamart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U1015, CBT1017</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CBT1017</wicri:noRegion>
<wicri:noRegion>INSERM, U1015, CBT1017</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U1015, CBT1017</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CBT1017</wicri:noRegion>
<wicri:noRegion>INSERM, U1015, CBT1017</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Portela Catani, Joao Paulo" sort="Portela Catani, Joao Paulo" uniqKey="Portela Catani J" first="João Paulo" last="Portela Catani">João Paulo Portela Catani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Laboratorio de Vetores Virais, Instituto do Coração, FM-USP</s1>
<s2>São Paulo</s2>
<s3>BRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Brésil</country>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duret, Helene" sort="Duret, Helene" uniqKey="Duret H" first="Helene" last="Duret">Helene Duret</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre</s1>
<s2>East Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>East Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W. L." last="Teng">Michele W. L. Teng</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s2>Herston, Queensland</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Herston, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Metabolomics and Cell Biology Platforms, Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yidan Wang" sort="Yidan Wang" uniqKey="Yidan Wang" last="Yidan Wang">YIDAN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U1015, CBT1017</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CBT1017</wicri:noRegion>
<wicri:noRegion>INSERM, U1015, CBT1017</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L." last="Schultze">Joachim L. Schultze</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Genomics & Immunoregulation, LIMES-Institute, University of Bonn</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stoll, Gautier" sort="Stoll, Gautier" uniqKey="Stoll G" first="Gautier" last="Stoll">Gautier Stoll</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U1015, CBT1017</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CBT1017</wicri:noRegion>
<wicri:noRegion>INSERM, U1015, CBT1017</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Université Paris Sud/Paris XI</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
<wicri:noRegion>Université Paris Sud/Paris XI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre</s1>
<s2>East Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>East Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>School of Medicine, University of Queensland</s1>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>School of Medicine, University of Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s2>Herston, Queensland</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Herston, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Metabolomics and Cell Biology Platforms, Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Université Paris Descartes/Paris V</s1>
<s2>Sorbonne Paris Cité</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes/Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Pole de Biologie, Hôpital Européen Georges Pompidou, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Cancer research : (Chicago, Ill.)</title>
<title level="j" type="abbreviated">Cancer res. : (Chic. Ill.)</title>
<idno type="ISSN">0008-5472</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Cancer research : (Chicago, Ill.)</title>
<title level="j" type="abbreviated">Cancer res. : (Chic. Ill.)</title>
<idno type="ISSN">0008-5472</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accessory cell</term>
<term>Antigen presenting cell</term>
<term>CC chemokine</term>
<term>CC-chemokine ligand 2</term>
<term>CCR2 chemokine receptor</term>
<term>Chemokine receptor</term>
<term>Chemotherapy</term>
<term>Malignant tumor</term>
<term>Monocyte chemoattractant protein 1</term>
<term>Recruitment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Protéine MCP1</term>
<term>Chimiokine CC</term>
<term>Récepteur chimiokine</term>
<term>Récepteur chimiokine CCR2</term>
<term>Recrutement</term>
<term>Cellule accessoire</term>
<term>Cellule APC</term>
<term>Tumeur maligne</term>
<term>Chimiothérapie</term>
<term>Chimiokine CCL2</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Recrutement</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell- and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b<sup>+</sup>
CD11c<sup>+</sup>
Ly6C<sup>high</sup>
Ly6G<sup>-</sup>
MHCII<sup>+</sup>
 dendritic cell-like antigen-presenting cells (APC) into the tumor bed, but not into lymphoid organs. Accordingly, draining lymph nodes turned out to be dispensable for the proliferation of tumor antigen-specific T cells within neoplastic lesions as induced by anthracyclines. In addition, we found that tumors treated with anthracyclines manifest increased expression levels of the chemokine Ccl2. Such a response is important as neoplasms growing in Ccl2<sup>-/-</sup>
 mice failed to accumulate dendritic cell-like APCs in response to chemotherapy. Moreover, cancers developing in mice lacking Ccl2 or its receptor (Ccr2) exhibited suboptimal therapeutic responses to anthracycline-based chemotherapy. Altogether, our results underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Brésil</li>
<li>France</li>
</country>
<region><li>District de Cologne</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>État de São Paulo</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bonn</li>
<li>Paris</li>
<li>São Paulo</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Yuting Ma" sort="Yuting Ma" uniqKey="Yuting Ma" last="Yuting Ma">YUTING MA</name>
</noRegion>
<name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name>
<name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name>
<name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name>
<name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name>
<name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name>
<name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name>
<name sortKey="Heng Yang" sort="Heng Yang" uniqKey="Heng Yang" last="Heng Yang">HENG YANG</name>
<name sortKey="Heng Yang" sort="Heng Yang" uniqKey="Heng Yang" last="Heng Yang">HENG YANG</name>
<name sortKey="Heng Yang" sort="Heng Yang" uniqKey="Heng Yang" last="Heng Yang">HENG YANG</name>
<name sortKey="Heng Yang" sort="Heng Yang" uniqKey="Heng Yang" last="Heng Yang">HENG YANG</name>
<name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name>
<name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name>
<name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name>
<name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Portela Catani, Joao Paulo" sort="Portela Catani, Joao Paulo" uniqKey="Portela Catani J" first="João Paulo" last="Portela Catani">João Paulo Portela Catani</name>
<name sortKey="Portela Catani, Joao Paulo" sort="Portela Catani, Joao Paulo" uniqKey="Portela Catani J" first="João Paulo" last="Portela Catani">João Paulo Portela Catani</name>
<name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name>
<name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name>
<name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name>
<name sortKey="Stoll, Gautier" sort="Stoll, Gautier" uniqKey="Stoll G" first="Gautier" last="Stoll">Gautier Stoll</name>
<name sortKey="Stoll, Gautier" sort="Stoll, Gautier" uniqKey="Stoll G" first="Gautier" last="Stoll">Gautier Stoll</name>
<name sortKey="Stoll, Gautier" sort="Stoll, Gautier" uniqKey="Stoll G" first="Gautier" last="Stoll">Gautier Stoll</name>
<name sortKey="Yidan Wang" sort="Yidan Wang" uniqKey="Yidan Wang" last="Yidan Wang">YIDAN WANG</name>
<name sortKey="Yidan Wang" sort="Yidan Wang" uniqKey="Yidan Wang" last="Yidan Wang">YIDAN WANG</name>
<name sortKey="Yidan Wang" sort="Yidan Wang" uniqKey="Yidan Wang" last="Yidan Wang">YIDAN WANG</name>
<name sortKey="Yuting Ma" sort="Yuting Ma" uniqKey="Yuting Ma" last="Yuting Ma">YUTING MA</name>
<name sortKey="Yuting Ma" sort="Yuting Ma" uniqKey="Yuting Ma" last="Yuting Ma">YUTING MA</name>
<name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mattarollo, Stephen R" sort="Mattarollo, Stephen R" uniqKey="Mattarollo S" first="Stephen R." last="Mattarollo">Stephen R. Mattarollo</name>
</noRegion>
<name sortKey="Duret, Helene" sort="Duret, Helene" uniqKey="Duret H" first="Helene" last="Duret">Helene Duret</name>
<name sortKey="Mattarollo, Stephen R" sort="Mattarollo, Stephen R" uniqKey="Mattarollo S" first="Stephen R." last="Mattarollo">Stephen R. Mattarollo</name>
<name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W. L." last="Teng">Michele W. L. Teng</name>
</country>
<country name="Brésil"><region name="État de São Paulo"><name sortKey="Portela Catani, Joao Paulo" sort="Portela Catani, Joao Paulo" uniqKey="Portela Catani J" first="João Paulo" last="Portela Catani">João Paulo Portela Catani</name>
</region>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L." last="Schultze">Joachim L. Schultze</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur les relations entre la France et l'Australie
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CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

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